Quinolines and derivatives
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Filtered Search Results
Accela Chembio Inc 1 | 2 | 3 | 4-tetrahydro-6-quinolinecarboxylic Acid | 5g | 5382-49-0 | MFCD00957087 | 97+% | Shelf Life: 1980 Days | Light Sensitive
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1 | 2 | 3 | 4-tetrahydro-6-quinolinecarboxylic Acid | 5g | 5382-49-0 | MFCD00957087 | 97+% | Shelf Life: 1980 Days | Light Sensitive
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Apexbio Technology LLC Matrine(Synonyms: Sophocarpidine, Matridin, (-)-Matrine, α-Matrine, (−)-α-Matrine, L-Matrine, Kushenin), 200mg, CAS: 519-02-8.
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Matrine (CAS 519-02-8) is an alkaloid derived from plants in the Sophora genus with demonstrated anticancer and anti-inflammatory activities It functions in part through agonism of kappa-opioid and possibly other receptors Matrine inhibits the MNK45 gastric cancer cell line proliferation (IC50 540 g/ml MTT assay) by modifying protein expression profiles (e g NF- B XIAP CIAP p-ERK) In vitro matrine induces apoptosis in NSCLC cells through ROS generation caspase activation and p38 pathway modulation Animal studies suggest therapeutic roles in cardiac injury and sepsis-related lung inflammation
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=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C=O.CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C=O | 100mg | 552750160](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-250.jpg)
eMolecules 103476-89-7 | Leupeptin hemisulfate | Ambeed | MFCD00037012 | 951.200 | C40H78N12O12S | 97.000 | OS(O)(=O)=O.CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C=O.CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C=O | 100mg | 552750160
Leupeptin hemisulfate | Ambeed | 103476-89-7 | MFCD00037012 | 951.200 | C40H78N12O12S | 97.000 | OS(O)(=O)=O.CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C=O.CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C=O | 100mg | 552750160
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Sigma Aldrich Fine Chemicals Biosciences Ethyl 4 Ntrobenzoate Phar100MG
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
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eMolecules 56-57-5 | 4-Nitroquinoline N-oxide | Ambeed | MFCD00006738 | 190.158 | C9H6N2O3 | 98.000 | [O-][N+](=O)c1cc[n+]([O-])c2ccccc12 | 250mg | 552801988
4-Nitroquinoline N-oxide | Ambeed | 56-57-5 | MFCD00006738 | 190.158 | C9H6N2O3 | 98.000 | [O-][N+](=O)c1cc[n+]([O-])c2ccccc12 | 250mg | 552801988
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000760476 6-BROMOHEXAN-1-AMINE 5G
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Apexbio Technology LLC Cyclosporin A 59865-13-3 200mg
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Cyclosporin A is an immunosuppressive agent acting primarily through inhibition of cyclophilins intracellular peptidyl-prolyl isomerases with a reported IC50 of 7 nM Cyclophilins regulate mitochondrial permeability transition pore (MPTP) opening intracellular calcium signaling and NFAT transcriptional activation pathways Cyclosporin A s ability to inhibit calcineurin-NFAT signaling in T-cell activation leads to suppression of inflammatory immune responses indicating potential use in autoimmune disorder research Additionally it modulates cell apoptosis and survival mechanisms in diverse models including retinal ischemic injury viral entry (HBV HCV) and tumor biology in colon cancer cell lines
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C1 | 5g | 551215926](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000474217.jpg-250.jpg)
eMolecules 1266339-10-9 | tert-butyl (3R)-3-fluoro-4-oxopiperidine-1-carboxylate | Pharmablock | MFCD28010938 | 217.240 | C10H16FNO3 | 97.000 | CC(C)(C)OC(=O)N1CCC(=O)[C@H](F)C1 | 5g | 551215926
tert-butyl (3R)-3-fluoro-4-oxopiperidine-1-carboxylate | Pharmablock | 1266339-10-9 | MFCD28010938 | 217.240 | C10H16FNO3 | 97.000 | CC(C)(C)OC(=O)N1CCC(=O)[C@H](F)C1 | 5g | 551215926
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eMolecules 2246-44-8 | 2-Methylnaphthalen-1-amine | Ambeed | MFCD00059135 | 157.216 | C11H11N | 95.000 | Cc1ccc2ccccc2c1N | 5g | 528570193
2-Methylnaphthalen-1-amine | Ambeed | 2246-44-8 | MFCD00059135 | 157.216 | C11H11N | 95.000 | Cc1ccc2ccccc2c1N | 5g | 528570193
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Apexbio Technology LLC CUDC-907 1339928-25-4 200mg
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CUDC-907 (CAS 1339928-25-4) is a dual inhibitor targeting histone deacetylases (HDACs 1 2 3 10) and class I phosphatidylinositol 3-kinases (PI3K) It exhibits nanomolar inhibitory activity against these enzymes blocking PI3K-mediated Akt signaling and increasing acetylation of histones and non-histone substrates (e g tubulin p53) In cancer cell models CUDC-907 induces G2-M phase arrest and reduces phosphorylation of downstream proteins such as p70S6 4EBP-1 MEK STAT3 and SRC Preclinical studies demonstrate its anti-tumor activity in lymphoma and NSCLC xenografts making it relevant for oncology research
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Apexbio Technology LLC A-966492 934162-61-5 200mg
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A-966492 (CAS 934162-61-5) is a potent inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1) exhibiting a Ki of 1 nM It also inhibits PARP-2 with a Ki of approximately 1 5 nM As a PARP inhibitor this compound interferes with the enzymatic activity essential for DNA repair pathways sensitizing cancer cells to cytotoxic therapies In vitro A-966492 shows effective inhibition in C41 cells with an EC50 of 1 nM and demonstrates moderate oral bioavailability (34-72%) and a half-life of around 1 7-1 9 hours It crosses the blood-brain barrier and has demonstrated activity in preclinical murine cancer models including B16F10 melanoma and BRCA1-deficient MX-1 breast cancer xenografts enhancing the efficacy of chemotherapeutic agents such as temozolomide and carboplatin
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eMolecules 343926-69-2 | 4-bromopyrimidin-2-amine | Pharmablock | MFCD09999168 | 174.001 | C4H4BrN3 | 97.000 | Nc1nccc(Br)n1 | 10g | 551195286
4-bromopyrimidin-2-amine | Pharmablock | 343926-69-2 | MFCD09999168 | 174.001 | C4H4BrN3 | 97.000 | Nc1nccc(Br)n1 | 10g | 551195286
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eMolecules 343926-69-2 | 4-bromopyrimidin-2-amine | Pharmablock | MFCD09999168 | 174.001 | C4H4BrN3 | 97.000 | Nc1nccc(Br)n1 | 5g | 551195285
4-bromopyrimidin-2-amine | Pharmablock | 343926-69-2 | MFCD09999168 | 174.001 | C4H4BrN3 | 97.000 | Nc1nccc(Br)n1 | 5g | 551195285
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Medchemexpress LLC Desonide | 638-94-8 | 99.2% | 200 MG
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Desonide is a non-fluorinated corticosteroid anti-inflammatory agent that acts on the glucocorticoid receptor. It can also specifically bind to the mutant huntingtin protein (mHTT), reducing the level and toxicity of mHTT. Desonide can be used in the research of Huntington's disease and inflammatory diseases such as atopic dermatitis.
- Non-fluorinated corticosteroid anti-inflammatory agent
- Modulates glucocorticoid receptor activity
- Specifically binds to mutant huntingtin protein (mHTT)
- Reduces mutant huntingtin protein (mHTT) levels and toxicity
- Used in Huntington's disease research
- Used in inflammatory disease research, such as atopic dermatitis
- Inhibits mHTT-induced cytotoxicity
- Reduces apoptotic signals and improves cell survival
- Demonstrates therapeutic effects in Huntington's disease mouse models
- Rescues behavioral deficits and lowers mHTT aggregates
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Medchemexpress LLC 3-sulfo-taurocholic acid disodium salt | 71781-33-4 | 99.0% | 639.73 | C26H43NNa2O10S2 | 1mg
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3-Sulfo-taurocholic Acid Disodium Salt (3-Sulfocholyl Taurine TCA3S) is a metabolite of the conjugated bile acid taurocholic acid Plasma levels of 3-Sulfo-taurocholic Acid Disodium Salt are elevated in wild-type and Sortilin 1 (Sort1) knockout mice at 6 hours following bile duct ligation (BDL) and are further elevated in Sort1 knockout mice at 24 hours post-BDL
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